Nfe2^tm1.1Hlpa
Targeted Allele Detail

Summary

• Symbol: Nfe2^tm1.1Hlpa
• Name: nuclear factor, erythroid derived 2; targeted mutation 1.1, Heike Luise Pahl
• MGI ID: MGI:6446746
• Synonyms: delta297-300
• Gene: Nfe2 Location: Chr15:103156640-103166809 bp, - strand Genetic Position: Chr15, 58.62 cM
• Alliance: Nfe2^tm1.1Hlpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:275444
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was replaced with one in which amino acids 297 to 300 were deleted. A loxP-flanked neomycin selection cassette was inserted upstream of exon 3 and was removed via cre-mediated recombination. Western blot analysis indicates increased protein levels compared to wild-type mice. (J:275444)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfe2 Mutation: 20 strains or lines available

References

• Original: J:275444 Jutzi JS, et al., Altered NFE2 activity predisposes to leukemic transformation and myelosarcoma with AML-specific aberrations. Blood. 2019 Apr 18;133(16):1766-1777
• All: 1 reference(s)