Mavs^los
Chemically induced Allele Detail

Summary

• Symbol: Mavs^los
• Name: mitochondrial antiviral signaling protein; machtlos
• MGI ID: MGI:6445612
• Gene: Mavs Location: Chr2:131075983-131089945 bp, + strand Genetic Position: Chr2, 63.3 cM
• Alliance: Mavs^los page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU treatment caused a T-to-C mutation that leads to the substitution of a highly conserved leucine with proline at position 480 (p.L480P) in the transmembrane domain. (J:254874)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mavs Mutation: 38 strains or lines available

References

• Original: J:254874 Loetsch C, et al., Cytosolic Recognition of RNA Drives the Immune Response to Heterologous Erythrocytes. Cell Rep. 2017 Nov 7;21(6):1624-1638
• All: 1 reference(s)