Gt(ROSA)26Sor^{tm1(CAG-TMEM192)Dmsa}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-TMEM192)Dmsa}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, David Sabatini
• MGI ID: MGI:6444758
• Synonyms: conditional LysoTag, Rosa26;lox-stop-lox-TMEM192-3xHA
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-TMEM192)Dmsa} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:329200
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, Epitope tag, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CAG-TMEM192)Dmsa} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TMEM192 (201931)

  Tmem192

  (MGI:1920317)

• Mutation details: A CAG-loxP-neomycin-Stop-loxP-FRT-TMEM192-3xHA-FRT-pA cassette incorporating full-length human TMEM192 cDNA coding sequences fused to a 3x hemagglutinin tag was introduced to intron 1. (J:329200)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 944 strains or lines available

References

• Original: J:329200 Laqtom NN, et al., CLN3 is required for the clearance of glycerophosphodiesters from lysosomes. Nature. 2022 Sep;609(7929):1005-1011
• All: 2 reference(s)