Il27ra^em1Ygch
Endonuclease-mediated Allele Detail

Summary

• Symbol: Il27ra^em1Ygch
• Name: interleukin 27 receptor, alpha; endonuclease-mediated mutation 1, Yi-Guang Chen
• MGI ID: MGI:6444746
• Synonyms: Il27ra^-
• Gene: Il27ra Location: Chr8:84756923-84769218 bp, - strand Genetic Position: Chr8, 40.26 cM, cytoband C3
• Alliance: Il27ra^em1Ygch page

Mutation origin

• Strain of Origin: NOD/ShiLtJ

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing is used to target the second coding exon resulting in a 34 bp deletion predicted to disrupt the normal reading frame. (J:285456)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il27ra Mutation: 31 strains or lines available

References

• Original: J:285456 Ciecko AE, et al., Interleukin-27 Is Essential for Type 1 Diabetes Development and Sjogren Syndrome-like Inflammation. Cell Rep. 2019 Dec 3;29(10):3073-3086.e5
• All: 3 reference(s)