Il27^em1Ygch
Endonuclease-mediated Allele Detail

Summary

• Symbol: Il27^em1Ygch
• Name: interleukin 27; endonuclease-mediated mutation 1, Yi-Guang Chen
• MGI ID: MGI:6444742
• Gene: Il27 Location: Chr7:126188182-126194113 bp, - strand Genetic Position: Chr7, 69.18 cM
• Alliance: Il27^em1Ygch page

Mutation origin

• Strain of Origin: NOD/ShiLtJ

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This zinc finger nuclease induced mutation targets exon 4 (target sequence CTACCACACTTCGGCCCTtccctGCCATGCTGGGAGGGCTG) creating a 1 bp deletion that introduces a premature stop codon.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il27 Mutation: 23 strains or lines available

References

• Original: J:285456 Ciecko AE, et al., Interleukin-27 Is Essential for Type 1 Diabetes Development and Sjogren Syndrome-like Inflammation. Cell Rep. 2019 Dec 3;29(10):3073-3086.e5
• All: 3 reference(s)