Cx3cr1^{tm3.1(Hbegf)Litt}
Targeted Allele Detail

Summary

• Symbol: Cx3cr1^{tm3.1(Hbegf)Litt}
• Name: C-X3-C motif chemokine receptor 1; targeted mutation 3.1, Dan R Littman
• MGI ID: MGI:6444724
• Synonyms: Cx3cr1^DTR
• Gene: Cx3cr1 Location: Chr9:119877749-119897362 bp, - strand Genetic Position: Chr9, 71.37 cM
• Alliance: Cx3cr1^{tm3.1(Hbegf)Litt} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:291075
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Not Specified)
• Mutation: Insertion
• Cx3cr1^{tm3.1(Hbegf)Litt} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Hbegf

• Mutation details: A targeting vector containing a loxP-Stop-loxP-diptheria toxin receptor (DTR)-IRES-YFP cassette was inserted into exon 1. Cre-mediated recombination removed the loxP-stop sequences. (J:291075)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cx3cr1 Mutation: 49 strains or lines available

References

• Original: J:291075 Longman RS, et al., CX(3)CR1(+) mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22. J Exp Med. 2014 Jul 28;211(8):1571-83
• All: 5 reference(s)