Drg2^tm1Jgwp
Targeted Allele Detail

Summary

• Symbol: Drg2^tm1Jgwp
• Name: developmentally regulated GTP binding protein 2; targeted mutation 1, Jeong Woo Park
• MGI ID: MGI:6444651
• Gene: Drg2 Location: Chr11:60345442-60359589 bp, + strand Genetic Position: Chr11, 37.81 cM
• Alliance: Drg2^tm1Jgwp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:291077
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exons 1 and 2. Western blot analysis confirmed the absence of protein expression. (J:291077)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Drg2 Mutation: 31 strains or lines available

References

• Original: J:291077 Mani M, et al., Developmentally regulated GTP-binding protein 2 coordinates Rab5 activity and transferrin recycling. Mol Biol Cell. 2016 Jan 15;27(2):334-48
• All: 2 reference(s)