Appl1^tm1Smoc
Targeted Allele Detail

Summary

• Symbol: Appl1^tm1Smoc
• Name: adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1; targeted mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:6444152
• Synonyms: Appl1^{tm1(flox)Smoc}
• Gene: Appl1 Location: Chr14:26640943-26692567 bp, - strand Genetic Position: Chr14, 16.09 cM, cytoband B
• Alliance: Appl1^tm1Smoc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:290466
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 5 was floxed. (J:290466)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Appl1 Mutation: 47 strains or lines available

References

• Original: J:290466 Fan L, et al., Adaptor protein APPL1 coordinates HDAC3 to modulate brown adipose tissue thermogenesis in mice. Metabolism. 2019 Nov;100:153955
• All: 2 reference(s)