Clic1^em2Tcp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Clic1^em2Tcp
• Name: chloride intracellular channel 1; endonuclease-mediated mutation 2, The Centre for Phenogenomics
• MGI ID: MGI:6441900
• Synonyms: Clic1_em2_del
• Gene: Clic1 Location: Chr17:35269219-35277695 bp, + strand Genetic Position: Chr17, 18.58 cM
• Alliance: Clic1^em2Tcp page

Mutation origin

• Strain of Origin: C57BL/6NCrl

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting produced a 1,458-bp deletion in chromosome 17 (35,052,089 to 35,053,546), which spans from intron 1-2 to intron 4-5. (J:289658)

Expression

In Mice Carrying this Mutation:

7 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Clic1 Mutation: 15 strains or lines available

References

• Original: J:289658 Francisco MA, et al., Chloride intracellular channel 1 cooperates with potassium channel EAG2 to promote medulloblastoma growth. J Exp Med. 2020 May 4;217(5)
• All: 1 reference(s)