Runx1^tm4.1Itan
Targeted Allele Detail

Summary

• Symbol: Runx1^tm4.1Itan
• Name: runt related transcription factor 1; targeted mutation 4.1, Ichiro Taniuchi
• MGI ID: MGI:6441730
• Synonyms: Runx1^P2TAG
• Gene: Runx1 Location: Chr16:92398354-92622962 bp, - strand Genetic Position: Chr16, 53.7 cM
• Alliance: Runx1^tm4.1Itan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:245723
• Parent Cell Line: M1/M-1 (ES Cell)
• Strain of Origin: (129 x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Intragenic deletion, Nucleotide substitutions
• Mutation details: The translation start codon, AUG, in exon 2 was replaced with a stop codon, UAG, and removed around 200 bp upstream of the putative transcriptional start site of promoter 2. This allele maintains expression from promoter 1 (P1), but not promoter 2 (P2). Cre-mediated recombination removed the flocked neomycin resistance cassette. (J:245723)

Expression

In Mice Carrying this Mutation:

12 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Runx1 Mutation: 34 strains or lines available

References

• Original: J:245723 Nieke S, et al., Unique N-terminal sequences in two Runx1 isoforms are dispensable for Runx1 function. BMC Dev Biol. 2017 Oct 18;17(1):14
• All: 1 reference(s)