Snca^tm1.1Kluk
Targeted Allele Detail

Summary

• Symbol: Snca^tm1.1Kluk
• Name: synuclein, alpha; targeted mutation 1.1, Kelvin Luk
• MGI ID: MGI:6441434
• Synonyms: Snca^GFP
• Gene: Snca Location: Chr6:60708559-60806839 bp, - strand Genetic Position: Chr6, 29.15 cM
• Alliance: Snca^tm1.1Kluk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:302425
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert a loxP flanked neomycin resistance (neo) cassette, followed by an enhanced green fluorescent protein (EGFP) sequence, directly after the C-terminus of the the gene. Cre-mediated recombination removed the upstream floxed neo cassette. (J:302425)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Snca Mutation: 44 strains or lines available

References

• Original: J:302425 Caputo A, et al., Snca-GFP Knock-In Mice Reflect Patterns of Endogenous Expression and Pathological Seeding. eNeuro. 2020 Jul/Aug;7(4):ENEURO.0007-20.2020
• All: 1 reference(s)