Picalm^em1Aduci
Endonuclease-mediated Allele Detail

Summary

• Symbol: Picalm^em1Aduci
• Name: phosphatidylinositol binding clathrin assembly protein; endonuclease-mediated mutation 1, Frank LaFerla
• MGI ID: MGI:6441030
• Synonyms: Picalm^H465R
• Gene: Picalm Location: Chr7:89779418-89858655 bp, + strand Genetic Position: Chr7, 50.47 cM
• Alliance: Picalm^em1Aduci page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 genome editing is used to create a CAT to AGA mutation, resulting in a histidine to arginine change at amino acid 465 (H465R) of the gene. This mutation H465R is homologous to the human SNP, H458R, shown to correlate with increased risk of Alzheimer's disease. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Picalm Mutation: 42 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)