Scnm1^r
Spontaneous Allele Detail

Summary

• Symbol: Scnm1^r
• Name: sodium channel modifier 1; resistance
• MGI ID: MGI:6436682
• Synonyms: Scnm1⁺, Scnm1^rs13474321-G
• Gene: Scnm1 Location: Chr3:95037030-95041285 bp, - strand Genetic Position: Chr3, 40.74 cM, cytoband F2
• Alliance: Scnm1^r page

Mutation origin

• Strain of Origin: multiple strains

Mutation description

• Allele Type: Spontaneous (Not Applicable)
• Mutation: Single point mutation
• Mutation details: The G variant (C on negative gene strand) of SNP rs13474321 is the major wild-type variant, coding for arginine at codon 187, found in the majority of strains. Most C57 strains like C57BL/6J and C57BL/6NJ plus C58 have the deleterious A variant, (T on gene strand) that codes for a stop codon at position 187. (J:84898)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scnm1 Mutation: 17 strains or lines available

References

• Original: J:53340 Sprunger LK, et al., Dystonia associated with mutation of the neuronal sodium channel Scn8a and identification of the modifier locus Scnm1 on mouse chromosome 3. Hum Mol Genet. 1999 Mar;8(3):471-9
• All: 2 reference(s)