Degs1^tm1.1Nju
Targeted Allele Detail

Summary

• Symbol: Degs1^tm1.1Nju
• Name: delta 4-desaturase, sphingolipid 1; targeted mutation 1.1, Model Animal Research Center of Nanjing University
• MGI ID: MGI:6436577
• Synonyms: Des1^F
• Gene: Degs1 Location: Chr1:182103529-182110366 bp, - strand Genetic Position: Chr1, 84.93 cM, cytoband H5
• Alliance: Degs1^tm1.1Nju page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:289101
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2 was flanked by loxP sites and a FRT-flanked neomycin resistance gene was inserted between exons 2 and 3 upstream of the second loxP site. Flp-mediated recombination removed the selection cassette. (J:289101)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Degs1 Mutation: 25 strains or lines available

References

• Original: J:289101 Kiser PD, et al., Conditional deletion of Des1 in the mouse retina does not impair the visual cycle in cones. FASEB J. 2019 Apr;33(4):5782-5792
• All: 2 reference(s)