Zfp36^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Zfp36^tm1.1Geno
• Name: zinc finger protein 36; targeted mutation 1.1, Genoway
• MGI ID: MGI:6432860
• Synonyms: Zfp36aa
• Gene: Zfp36 Location: Chr7:28076208-28078680 bp, - strand Genetic Position: Chr7, 16.72 cM
• Alliance: Zfp36^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:269801
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: Nucleotide changes resulted in the amino acid substitution of serine to alanine at positions 52 and 178. Cre-mediated recombination removed the neomycin resistance cassette inserted in intron 2. (J:269801)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfp36 Mutation: 17 strains or lines available

References

• Original: J:269801 Ross EA, et al., Dominant Suppression of Inflammation via Targeted Mutation of the mRNA Destabilizing Protein Tristetraprolin. J Immunol. 2015 Jul 1;195(1):265-76
• All: 4 reference(s)