Hprt1^{tm1(CAG-mClover*)Hadj}
Targeted Allele Detail

Summary

• Symbol: Hprt1^{tm1(CAG-mClover*)Hadj}
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Anna-Katerina Hadjantonakis
• MGI ID: MGI:6432798
• Synonyms: Hprt^ERK-KTR
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^{tm1(CAG-mClover*)Hadj} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: The targeting construct includes a CAGGS enhancer/promoter sequenceand a rabbit beta-globin poly-A sequence directing expression of the ERK-KTR-mClover reporter. The reporter consists of a docking site (a fragment of human ELK1, an ERK substrate), nuclear localization (NLS) and export (NES) signals, and mClover green/yellow fluorescent protein derived from Aequorea victoria. Clover differs from GFP by the following modifications - M1_S2insV/S30R/Y39N/S65G/Q69A/F99S/N105T/Y145F/M153T/V163A/I171V/T203H. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1280 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 2 reference(s)