Sik1^em1Iiis
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sik1^em1Iiis
• Name: salt inducible kinase 1; endonuclease-mediated mutation 1, Masashi Yanagisawa and Hiromasa Funato
• MGI ID: MGI:6431081
• Synonyms: Sik1^S577A
• Gene: Sik1 Location: Chr17:32063224-32074778 bp, - strand Genetic Position: Chr17, 17.25 cM
• Alliance: Sik1^em1Iiis page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• CRISPR-targeting introduced the amino acid substitution of alanine for serine at position 577. (J:288218)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sik1 Mutation: 40 strains or lines available

References

• Original: J:288218 Park M, et al., Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need. Sci Rep. 2020 May 26;10(1):8676
• All: 1 reference(s)