Mob1b^tm1.1Hlee
Targeted Allele Detail

Summary

• Symbol: Mob1b^tm1.1Hlee
• Name: MOB kinase activator 1B; targeted mutation 1.1, Ho Lee
• MGI ID: MGI:6430420
• Synonyms: Mob1b^f
• Gene: Mob1b Location: Chr5:88868730-88906314 bp, + strand Genetic Position: Chr5, 43.92 cM, cytoband E2
• Alliance: Mob1b^tm1.1Hlee page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:288139
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 3 was floxed. Flp-mediated recombination removed the FRT-flanked puromycin cassette. (J:288139)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mob1b Mutation: 19 strains or lines available

References

• Original: J:288139 Bae JS, et al., Depletion of MOB1A/B causes intestinal epithelial degeneration by suppressing Wnt activity and activating BMP/TGF-beta signaling. Cell Death Dis. 2018 Oct 22;9(11):1083
• All: 1 reference(s)