Retnla^tm1.1Nair
Targeted Allele Detail

Summary

• Symbol: Retnla^tm1.1Nair
• Name: resistin like alpha; targeted mutation 1.1, Meera Nair
• MGI ID: MGI:6423707
• Gene: Retnla Location: Chr16:48662972-48664824 bp, + strand Genetic Position: Chr16, 30.75 cM, cytoband B5
• Alliance: Retnla^tm1.1Nair page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94077
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change, Reporter)
• Mutation: Insertion
• Mutation details: A reporter marker cassette was inserted in antisense orientation downstream of exon 4, such that cre-mediated deletion of the targeted exon 2 to exon 4 will flip the reporter gene (tdTomato) into sense orientation leading to its expression. To enhance the stability of the reporter messenger and to increase the chance of having a bright signal, a WPRE sequence (woodchuck hepatitis virus post-transcriptional regulatory element) was added to the construct. The selection cassette was removed with a Flp recombinase strain. (J:94077)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Retnla Mutation: 13 strains or lines available

References

• Original: J:350365 Li J, et al., Macrophage-Regulatory T Cell Interactions Promote Type 2 Immune Homeostasis Through Resistin-Like Molecule alpha. Front Immunol. 2021;12:710406
• All: 3 reference(s)