Ctnnd2^em2Arikk
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ctnnd2^em2Arikk
• Name: catenin delta 2; endonuclease-mediated mutation 2, Jyothi Arikkath
• MGI ID: MGI:6423555
• Synonyms: Ctnnd2^{em2(G34S)Arikk}
• Gene: Ctnnd2 Location: Chr15:30172739-31029487 bp, + strand Genetic Position: Chr15, 12.02 cM
• Alliance: Ctnnd2^em2Arikk page

Mutation origin

• Strain of Origin: C57BL/6NCrl

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting introduced a G to A change that produces the amino acid substitution of serine for glycine at position 34 (G34S). The p.G34S mutation is associated with autism spectrum disorder in humans. (J:342969)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ctnnd2 Mutation: 65 strains or lines available

References

• Original: J:342969 Mendez-Vazquez H, et al., The autism-associated loss of delta-catenin functions disrupts social behavior. Proc Natl Acad Sci U S A. 2023 May 30;120(22):e2300773120
• All: 2 reference(s)