Smad7^tm1.1Tchi
Targeted Allele Detail

Summary

• Symbol: Smad7^tm1.1Tchi
• Name: SMAD family member 7; targeted mutation 1.1, Tomoki Chiba
• MGI ID: MGI:6423522
• Gene: Smad7 Location: Chr18:75500600-75529006 bp, + strand Genetic Position: Chr18, 51.06 cM, cytoband E2
• Alliance: Smad7^tm1.1Tchi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:287775
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: LoxP sites and an frt-flanked neomycin selection cassette were inserted to flank exon 4 of the gene. Exon 4 was removed via Cre-mediated recombination in the germline. (J:287775)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Smad7 Mutation: 53 strains or lines available

References

• Original: J:287775 Tojo M, et al., Smad7-deficient mice show growth retardation with reduced viability. J Biochem. 2012 Jun;151(6):621-31
• All: 1 reference(s)