Hira^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Hira^tm1.1Geno
• Name: histone cell cycle regulator; targeted mutation 1.1, Genoway
• MGI ID: MGI:6423079
• Synonyms: Hira^f
• Gene: Hira Location: Chr16:18695787-18789059 bp, + strand Genetic Position: Chr16, 11.69 cM, cytoband A-B1
• Alliance: Hira^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:286991
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites were insterted to flank exon 7 of the gene. A neomycin selection cassette flanked by frt sites were inserted in the sequence between exon 6 and exon 8 of the endogenous allele. Flp-mediated recombination in the germline removed the neomycin cassette. (J:286991)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hira Mutation: 75 strains or lines available

References

• Original: J:286991 Chen C, et al., HIRA, a DiGeorge Syndrome Candidate Gene, Confers Proper Chromatin Accessibility on HSCs and Supports All Stages of Hematopoiesis. Cell Rep. 2020 Feb 18;30(7):2136-2149.e4
• All: 1 reference(s)