Sesn1^tm1.2Moli
Targeted Allele Detail

Summary

• Symbol: Sesn1^tm1.2Moli
• Name: sestrin 1; targeted mutation 1.2 Ming Li
• MGI ID: MGI:6414891
• Synonyms: Sesn1 KO
• Gene: Sesn1 Location: Chr10:41686570-41784432 bp, + strand Genetic Position: Chr10, 22.77 cM
• Alliance: Sesn1^tm1.2Moli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:214946
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A single loxP site was inserted into intron 1, and a Neo cassette with a loxp site was inserted between exon 6 and exon 7. The neo cassette and exons 1-7 were removed via flp and cre-mediated recombination. (J:214946)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sesn1 Mutation: 66 strains or lines available

References

• Original: J:214946 Peng M, et al., Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling. Cell. 2014 Sep 25;159(1):122-33
• All: 1 reference(s)