Gm10521^em1Vei
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gm10521^em1Vei
• Name: predicted gene 10521; endonuclease-mediated mutation 1, Andre Veillette
• MGI ID: MGI:6407433
• Gene: Gm10521 Location: Chr1:171723231-171725804 bp, + strand Genetic Position: Chr1, 79.54 cM
• Alliance: Gm10521^em1Vei page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting created a frameshift mutation through deletion of five nucleotides at the 5' end of the potential coding sequence. (J:237231)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gm10521 Mutation: 5 strains or lines available

References

• Original: J:237231 Guo H, et al., Deletion of Slam locus in mice reveals inhibitory role of SLAM family in NK cell responses regulated by cytokines and LFA-1. J Exp Med. 2016 Sep 19;213(10):2187-207
• All: 1 reference(s)