Gt(ROSA)26Sor^{tm1(CAG-LMNA*)Cyh}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-LMNA*)Cyh}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Ya-Hui Chi
• MGI ID: MGI:6407423
• Synonyms: CAG-Progerin⁺
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-LMNA*)Cyh} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:284048
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Epitope tag, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CAG-LMNA*)Cyh} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  LMNA (4000)

  Lmna	(MGI:96794)

  expresses the mutant lamin A progerin protein

• Mutation details: A flag-tagged human progerin (the lamin A mutant protein that causes Hutchinson-Gilford progeria syndrome) cDNA and a loxP-flanked PGK-neo cassette upstream of the human cDNA were inserted into the locus. (J:284048)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 944 strains or lines available

References

• Original: J:284048 Wang WP, et al., Progerin in muscle leads to thermogenic and metabolic defects via impaired calcium homeostasis. Aging Cell. 2020 Feb;19(2):e13090
• All: 1 reference(s)