Gt(ROSA)26Sor^{tm1(CAG-Trib1)Psou}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-Trib1)Psou}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Pauline Soulas-Sprauel
• MGI ID: MGI:6406406
• Synonyms: Gt(ROSA)26Sor^{tm1(Trib1)Psou}, Trib1-ROSA KI
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-Trib1)Psou} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:286685
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector inserted the coding sequence for murine Trib1, preceded by the synthetic CAG promoter and a loxP-flanked neo-STOP cassette, into the ubiquitously expressed locus. (J:286685)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1058 strains or lines available

References

• Original: J:286685 Simoni L, et al., Trib1 Is Overexpressed in Systemic Lupus Erythematosus, While It Regulates Immunoglobulin Production in Murine B Cells. Front Immunol. 2018;Mar 15(9):373
• All: 1 reference(s)