Grin2a^tm2Rsp
Targeted Allele Detail

Summary

• Symbol: Grin2a^tm2Rsp
• Name: glutamate receptor, ionotropic, NMDA2A (epsilon 1); targeted mutation 2, Rolf Sprengel
• MGI ID: MGI:6406404
• Synonyms: Grin2a(N615S), Grin2a^S, Grin2a^{tm1.RSP(N615S)}
• Gene: Grin2a Location: Chr16:9385762-9813424 bp, - strand Genetic Position: Chr16, 5.28 cM
• Alliance: Grin2a^tm2Rsp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:302959
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: Nucleotide substitution resulted in the amino acid change of serine for asparagine at position 615 (N615S). (J:302959)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grin2a Mutation: 66 strains or lines available

References

• Original: J:302959 Bertocchi I, et al., Voltage-independent GluN2A-type NMDA receptor Ca(2+) signaling promotes audiogenic seizures, attentional and cognitive deficits in mice. Commun Biol. 2021 Jan 8;4(1):59
• All: 2 reference(s)