Pilra^em1Dvst
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pilra^em1Dvst
• Name: paired immunoglobin-like type 2 receptor alpha; endonuclease-mediated mutation 1, Dietmar Vestweber
• MGI ID: MGI:6405408
• Gene: Pilra Location: Chr5:137820214-137834540 bp, - strand Genetic Position: Chr5, 76.77 cM
• Alliance: Pilra^em1Dvst page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR-targeting of exon 2 produced frameshift indels. Flow cytometry confirmed the absence of protein expression in permeabilized neutrophils. (J:286045)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pilra Mutation: 28 strains or lines available

References

• Original: J:286045 Li YT, et al., Blood flow guides sequential support of neutrophil arrest and diapedesis by PILR-beta1 and PILR-alpha. Elife. 2019 Aug 6;8:e47642
• All: 1 reference(s)