Trem2^m1
Spontaneous Allele Detail

Summary

• Symbol: Trem2^m1
• Name: triggering receptor expressed on myeloid cells 2; mutation 1
• MGI ID: MGI:6405379
• Synonyms: Trem2^S148E
• Gene: Trem2 Location: Chr17:48653429-48659304 bp, + strand Genetic Position: Chr17, 23.99 cM, cytoband C
• Alliance: Trem2^m1 page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Spontaneous (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: This allele represents the "mutated" (less frequently found) GA version of co-segregating SNPs rs108080490 (T/G) and rs107649577 (C/A), as found in the 129P2/OlaHsd, 129S1/SvImJ, 129S5SvEvBrd, BTBR/J, CASA, CAST/EiJ, CZECH, FL, JF1, LP/J, MOLF, MOLG, MSM, NZW, PWD, PWK/PhJ, SF, SJL/J, SKIVE, and SPRET/EiJ strains. The TC>GA substitution causes codon 148 to change from serine to glutamic acid (p.S148E). The "wild-type" TC genotype is found in the A/J, AKR/J, BALB/cJ, C3H/HeJ, C57BL/6NJ, CBA/J, DBA/2J, FVB/NJ, NOD/ShiLtJ, NZO/HILtJ, and WSB/EiJ strains. (J:101977)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trem2 Mutation: 65 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)