Cyp1a1^{tm2025.1(CYP1A1)Arte}
Targeted Allele Detail

Summary

• Symbol: Cyp1a1^{tm2025.1(CYP1A1)Arte}
• Name: cytochrome P450, family 1, subfamily a, polypeptide 1; targeted mutation 2025.1, TaconicArtemis
• MGI ID: MGI:6405045
• Gene: Cyp1a1 Location: Chr9:57595211-57611107 bp, + strand Genetic Position: Chr9, 31.34 cM
• Alliance: Cyp1a1^{tm2025.1(CYP1A1)Arte} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:278424
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Cyp1a1^{tm2025.1(CYP1A1)Arte} involves 1 genes/genome features (Cyp1a1) View all
• Cyp1a1^{tm2025.1(CYP1A1)Arte} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CYP1A1 (1543)

  Cyp1a1

  (MGI:88588)

• Mutation details: The mouse coding sequence was replaced with the corresponding sequence for human CYP1A1 with insertion downstream of the 3' UTR of a polyadenylationsequence, FRT-flanked neyomysin resistance cassette and loxP site. Flp-mediated recombination removed the selection cassette. (J:278424)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyp1a1 Mutation: 35 strains or lines available

References

• Original: J:278424 Kapelyukh Y, et al., Defining the Contribution of CYP1A1 and CYP1A2 to Drug Metabolism Using Humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 Knockout Mice. Drug Metab Dispos. 2019 Aug;47(8):907-918
• All: 2 reference(s)