Cyp2c^tm1104Arte
Targeted Allele Detail

Summary

• Symbol: Cyp2c^tm1104Arte
• Name: cytochrome P450, family 2, subfamily c cluster; targeted mutation 1104, TaconicArtemis
• MGI ID: MGI:6404559
• Synonyms: Cyp2c^KO, Del(19Cyp2c55-Cyp2c70)Arte
• Gene: Cyp2c Location: unknown Genetic Position: Chr19, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:241121
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Cyp2c^tm1104Arte involves 18 genes/genome features (Cyp2c55, Gm3875, Cyp2c65 ...) View all
• Mutation details: Cre-mediated recombination between a thymidine kinase expression cassette, hygromycin resistance cassette, loxP site, lox5171 and FRT site inserted into intron 6 of Cyp2c55 and an f3 site, promoter, loxP site, neomycin resistance gene, thymidine kinase expression cassette inserted into intron 1 of Cyp2c70 deleted the intervening sequence. (J:241121)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyp2c Mutation: 0 strains or lines available

References

• Original: J:241121 Scheer N, et al., Generation and characterization of novel cytochrome P450 Cyp2c gene cluster knockout and CYP2C9 humanized mouse lines. Mol Pharmacol. 2012 Dec;82(6):1022-9
• All: 5 reference(s)