Sod1^{tm1.2(SOD1)Emcf}
Targeted Allele Detail

Summary

• Symbol: Sod1^{tm1.2(SOD1)Emcf}
• Name: superoxide dismutase 1, soluble; targeted mutation 1.2, Elizabeth MC Fisher
• MGI ID: MGI:6403196
• Gene: Sod1 Location: Chr16:90017650-90023221 bp, + strand Genetic Position: Chr16, 51.56 cM, cytoband B5-C3
• Alliance: Sod1^{tm1.2(SOD1)Emcf} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90559
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Humanized sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The mouse sequence is replaced with the human sequence that has a floxed duplication of exons 4 and 5. An FRT-flanked selection cassette was inserted downstream of the first human exon 5. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed the first set of human exon 4 and 5. (J:90559)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sod1 Mutation: 47 strains or lines available

References

• Original: J:90559 The Mammalian Genetics Unit at Harwell, Information obtained from the Mammalian Genetics Unit, Medical Research Council (MRC), Harwell, UK. Unpublished. 2004-2013
• All: 1 reference(s)