Tg(CAG-ACE2)AC22Ctkt
Transgene Detail

Summary

• Symbol: Tg(CAG-ACE2)AC22Ctkt
• Name: transgene insertion AC22, Chien-Te K Tseng
• MGI ID: MGI:6402929
• Synonyms: AC22
• Transgene: Tg(CAG-ACE2)AC22Ctkt Location: unknown
• Alliance: Tg(CAG-ACE2)AC22Ctkt page

Transgene origin

• Strain of Origin: (C57BL/6J x C3H/HeJ)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-ACE2)AC22Ctkt expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ACE2 (59272)

  Ace2	(MGI:1917258)

• Mutation details: The human ACE2 cDNA is under the control of the CAG promoter (consisting of the cytomegalovirus immediate-early enhancer and the chicken beta-actin promoter). Five lines (AC12, AC22, AC50, AC63, and AC70) were generated. While this line is susceptible to infection with severe acute respiratory syndrome coronavirus, it is resistant to lethality following infection. (J:117824, J:148946)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:117824 Tseng CT, et al., Severe acute respiratory syndrome coronavirus infection of mice transgenic for the human Angiotensin-converting enzyme 2 virus receptor. J Virol. 2007 Feb;81(3):1162-73
• All: 3 reference(s)