Serpinb2^em1Asuh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Serpinb2^em1Asuh
• Name: serine (or cysteine) peptidase inhibitor, clade B, member 2; endonuclease-mediated mutation 1, Andreas Suhrbier
• MGI ID: MGI:6402920
• Synonyms: SerpinB2^R380A
• Gene: Serpinb2 Location: Chr1:107439153-107453330 bp, + strand Genetic Position: Chr1, 50.34 cM
• Alliance: Serpinb2^em1Asuh page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: The active site (P1) Arg38020 (codon AGA) of Serpinb2 was changed to Ala380 (codon GCA); i.e. nucleotides 1222 and 1223 (with reference to accession NM_011111.4) were changed from AG to GC. Two silent mutations were also introduced to prevent cutting of the oligonucleotide during genome editing. (J:286308)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Serpinb2 Mutation: 31 strains or lines available

References

• Original: J:286308 Schroder WA, et al., SerpinB2 inhibits migration and promotes a resolution phase signature in large peritoneal macrophages. Sci Rep. 2019 Aug 27;9(1):12421
• All: 1 reference(s)