Il27^tm1Yznz
Targeted Allele Detail

Summary

• Symbol: Il27^tm1Yznz
• Name: interleukin 27; targeted mutation 1, Zhinan Yin
• MGI ID: MGI:6402823
• Synonyms: IL27p28^f, Il27^tm1Ynzn, p28^f
• Gene: Il27 Location: Chr7:126188182-126194113 bp, - strand Genetic Position: Chr7, 69.18 cM
• Alliance: Il27^tm1Yznz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:272195
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. A floxed neomycin resistance cassette was inserted downstream of exon 4. (J:272195)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il27 Mutation: 23 strains or lines available

References

• Original: J:272195 Zhang S, et al., High susceptibility to liver injury in IL-27 p28 conditional knockout mice involves intrinsic interferon-gamma dysregulation of CD4+ T cells. Hepatology. 2013 Apr;57(4):1620-31
• All: 14 reference(s)