Cd28^{tm1.1(CD28)Geno}
Targeted Allele Detail

Summary

• Symbol: Cd28^{tm1.1(CD28)Geno}
• Name: CD28 antigen; targeted mutation 1.1, Genoway
• MGI ID: MGI:6402766
• Synonyms: Cd28^{tm1.1(hCD28)Geno}, Cd28^{tm1(huCD28-ICP16)Geno}
• Gene: Cd28 Location: Chr1:60785547-60812521 bp, + strand Genetic Position: Chr1, 30.52 cM, cytoband C1-C3
• Alliance: Cd28^{tm1.1(CD28)Geno} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:377554
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Cd28^{tm1.1(CD28)Geno} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CD28 (940)

  Cd28	(MGI:88327)

  Human/mouse fusion

• Mutation details: The CD28 humanized model was developed by Knockin of the human CD28 combo genomic/cDNA in frame with the mouse Cd28 exon 2. (J:286243, J:377554)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cd28 Mutation: 37 strains or lines available

References

• Original: J:377554 Majocchi S, et al., NI-3201 Is a Bispecific Antibody Mediating PD-L1-Dependent CD28 Co-stimulation on T Cells for Enhanced Tumor Control. Cancer Immunol Res. 2025;13(3):365-383
• All: 2 reference(s)