Tsc2^em2Daks
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tsc2^em2Daks
• Name: TSC complex subunit 2; endonuclease-mediated mutation 2, David A Kass
• MGI ID: MGI:6402466
• Synonyms: Tsc2^S1365A
• Gene: Tsc2 Location: Chr17:24814790-24851604 bp, - strand Genetic Position: Chr17, 12.41 cM
• Alliance: Tsc2^em2Daks page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR-targeting produced the amino acid substitution of alanine for serine at position 1365 (S1365A). (J:286196)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tsc2 Mutation: 79 strains or lines available

References

• Original: J:286196 Ranek MJ, et al., PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress. Nature. 2019 Feb;566(7743):264-269
• All: 4 reference(s)