Ahr^em2Bra
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ahr^em2Bra
• Name: aryl-hydrocarbon receptor; endonuclease-mediated mutation 2, Christopher A Bradfield
• MGI ID: MGI:6402397
• Synonyms: Ahr
• Gene: Ahr Location: Chr12:35547978-35584988 bp, - strand Genetic Position: Chr12, 15.78 cM
• Alliance: Ahr^em2Bra page

Mutation origin

• Strain of Origin: B6.129(FVB)-Ahr^tm3.1Bra/Bra

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9-targeting in Ahr^tm3.1Bra zygotes deleted three nucleotides that spans two amino acids resulting in the glycine at 367 and asparigine at 368 being condensed into an arginine at 367.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ahr Mutation: 109 strains or lines available

References

• Original: J:300133 Wilson RH, et al., Generation of an Allelic Series at the Ahr Locus Using an Edited Recombinant Approach. Toxicol Sci. 2021 Jan 22
• All: 1 reference(s)