Igh^tm1.1Jlh
Targeted Allele Detail

Summary

• Symbol: Igh^tm1.1Jlh
• Name: immunoglobulin heavy chain complex; targeted mutation 1.1, Jean Langhorne
• MGI ID: MGI:6402360
• Synonyms: Igh^NIMP23
• Gene: Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:286195
• Parent Cell Line: PRX-B6N (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The VDJH-NIMP23 anti-MSP121 variable region coding exon containing the Leader-V segment intron from gDNA of the NIMP23 hybridoma replacing theanti-HEL heavy chain variable region coding exon. Cre-mediated recombination removed the floxed neomycin resistance cassette. (J:286195)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh Mutation: 47 strains or lines available

References

• Original: J:286195 Prez-Mazliah D, et al., Plasmodium-specific atypical memory B cells are short-lived activated B cells. Elife. 2018;Nov 2(7):e39800
• All: 1 reference(s)