Lox^tm1.1Khki
Targeted Allele Detail

Summary

• Symbol: Lox^tm1.1Khki
• Name: lysyl oxidase; targeted mutation 1.1, Kathrin H Kirsch
• MGI ID: MGI:6401446
• Synonyms: LOX-PP^Gln
• Gene: Lox Location: Chr18:52649139-52662939 bp, - strand Genetic Position: Chr18, 28.22 cM
• Alliance: Lox^tm1.1Khki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:264295
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: An AG to CA change resulting in an arginine to glutamine substitution at amino acid 152 was introduced in the propeptide coding region. An FRT-flanked neomycin selection cassette was removed via Flp-mediated recombination. (J:264295)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lox Mutation: 21 strains or lines available

References

• Original: J:264295 de la Cueva A, et al., A polymorphism in the lysyl oxidase propeptide domain accelerates carcinogen-induced cancer. Carcinogenesis. 2018 Jul 3;39(7):921-930
• All: 2 reference(s)