Foxp1^tm1.1Ayr
Targeted Allele Detail

Summary

• Symbol: Foxp1^tm1.1Ayr
• Name: forkhead box P1; targeted mutation 1.1, Alexander Y Rudensky
• MGI ID: MGI:6400470
• Synonyms: Foxp1^fl
• Gene: Foxp1 Location: Chr6:98902299-99499682 bp, - strand Genetic Position: Chr6, 45.74 cM, cytoband E1
• Alliance: Foxp1^tm1.1Ayr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:282453
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP-FRT-PGK-neo-FRT-loxP cassette was introduced to intron 10, and a loxP site was placed in intron 11. Flp-mediated recombination removed the FRT-flanked neo cassette (J:282453)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Foxp1 Mutation: 77 strains or lines available

References

• Original: J:282453 Konopacki C, et al., Transcription factor Foxp1 regulates Foxp3 chromatin binding and coordinates regulatory T cell function. Nat Immunol. 2019 Feb;20(2):232-242
• All: 1 reference(s)