Tg(tetO-RNAi:Ptpn22,UBC-tetR,-GFP)P4Kslr
Transgene Detail

Summary

• Symbol: Tg(tetO-RNAi:Ptpn22,UBC-tetR,-GFP)P4Kslr
• Name: transgene lentiviral insertion P4, Stephen Kissler
• MGI ID: MGI:6393969
• Transgene: Tg(tetO-RNAi:Ptpn22,UBC-tetR,-GFP)P4Kslr Location: unknown
• Alliance: Tg(tetO-RNAi:Ptpn22,UBC-tetR,-GFP)P4Kslr page

Transgene origin

• Strain of Origin: NOD

Transgene description

• Transgene Type: Transgenic (Inducible, Knockdown, Reporter)
• Mutation: Insertion
• Tg(tetO-RNAi:Ptpn22,UBC-tetR,-GFP)P4Kslr involves 1 genes/genome features (Ptpn22) View all
• Mutation details: The tetracycline promoter drives inducible expression of the short hairpin RNA targeting Ptpn22 (GCATCTGTACACATCTTTA in line P4). A human ubiquitin C promoter drives ubiquitous expression of the tetracycline repressor and a GFP reporter gene. (J:208596)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:208596 Zheng P, et al., PTPN22 silencing in the NOD model indicates the type 1 diabetes-associated allele is not a loss-of-function variant. Diabetes. 2013 Mar;62(3):896-904
• All: 1 reference(s)