Adam17^em1Krss
Endonuclease-mediated Allele Detail

Summary

• Symbol: Adam17^em1Krss
• Name: a disintegrin and metallopeptidase domain 17; endonuclease-mediated mutation 1, Karina Reiss
• MGI ID: MGI:6393844
• Synonyms: Adam17^3x
• Gene: Adam17 Location: Chr12:21373510-21423633 bp, - strand Genetic Position: Chr12, 8.3 cM
• Alliance: Adam17^em1Krss page

Mutation origin

• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR-targeting of exon 15 induced the point mutations R625G, K626G, and K628G. An additional silent mutation (P629) was introduced for analytical purposes. (J:284798)

Expression

In Mice Carrying this Mutation:

8 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adam17 Mutation: 62 strains or lines available

References

• Original: J:284798 Veit M, et al., Mutagenesis of the ADAM17-phosphatidylserine-binding motif leads to embryonic lethality in mice. Life Sci Alliance. 2019 Oct;2(5)
• All: 1 reference(s)