Slc9a6^em2Moro
Endonuclease-mediated Allele Detail

Summary

• Symbol: Slc9a6^em2Moro
• Name: solute carrier family 9 (sodium/hydrogen exchanger), member 6; endonuclease-mediated mutation 2, Eric Morrow
• MGI ID: MGI:6392023
• Synonyms: NHE6-null
• Gene: Slc9a6 Location: ChrX:55655117-55709590 bp, + strand Genetic Position: ChrX, 30.06 cM
• Alliance: Slc9a6^em2Moro page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing is used to introduce a 4 bp CAAG deletionin exon 15. The mutation causes a frameshift that results in a premature stop codon. (J:284697)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc9a6 Mutation: 10 strains or lines available

References

• Original: J:284697 Ouyang Q, et al., Functional Assessment In Vivo of the Mouse Homolog of the Human Ala-9-Ser NHE6 Variant. eNeuro. 2019 Nov/Dec;6(6):ENEURO.0046-19.2019
• All: 2 reference(s)