Slc9a6^em1Moro
Endonuclease-mediated Allele Detail

Summary

• Symbol: Slc9a6^em1Moro
• Name: solute carrier family 9 (sodium/hydrogen exchanger), member 6; endonuclease-mediated mutation 1, Eric Morrow
• MGI ID: MGI:6392022
• Synonyms: NHE6A11S
• Gene: Slc9a6 Location: ChrX:55655117-55709590 bp, + strand Genetic Position: ChrX, 30.06 cM
• Alliance: Slc9a6^em1Moro page

Mutation origin

• Strain of Origin: C57BL/6NJ

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: Plasmids encoding guide RNA (ATG GCT GGG GCT CGG CGC GGC TGG CGG CTG TCG) were designed to introduce guanine to thymine point mutation in exon 1. The resulting exon 1 harbors an alanine to serine mutation at amino acid position 11 (A11S). There are no known off-target sites present. The A11S mutation in orthologous to the human A9S mutation found in Christianson syndrome patients. (J:284697)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc9a6 Mutation: 9 strains or lines available

References

• Original: J:284697 Ouyang Q, et al., Functional Assessment In Vivo of the Mouse Homolog of the Human Ala-9-Ser NHE6 Variant. eNeuro. 2019 Nov/Dec;6(6):ENEURO.0046-19.2019
• All: 1 reference(s)