Tg(CAG-OVAL*)2W72Jen
Transgene Detail

Summary

• Symbol: Tg(CAG-OVAL*)2W72Jen
• Name: transgene insertion 2W72, Marc K Jenkins
• MGI ID: MGI:6391385
• Synonyms: Act-2W
• Transgene: Tg(CAG-OVAL*)2W72Jen Location: unknown
• Alliance: Tg(CAG-OVAL*)2W72Jen page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-OVAL*)2W72Jen expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  chicken	OVAL (396058)

• Tg(CAG-OVAL*)2W72Jen expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  chicken	CAG

• Mutation details: This randomly integrated transgene encodes a membrane-bound (using the transmembrane domain of the mouse H2-Db) version of chicken ovalbumin in which additional T cell antigenic peptide epitopes are embedded. These additional epitopes include 2W1S (EAWGALANWAVDSA), which function as a self-antigen (2W). Expression is driven by the CAG (beta actin) promoter. (J:175217)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:175217 Moon JJ, et al., Quantitative impact of thymic selection on Foxp3+ and Foxp3- subsets of self-peptide/MHC class II-specific CD4+ T cells. Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):14602-7
• All: 11 reference(s)