H2-Ab1^g7-em2Ygch
Endonuclease-mediated Allele Detail

Summary

• Symbol: H2-Ab1^g7-em2Ygch
• Name: histocompatibility 2, class II antigen A, beta 1; endonuclease-mediated mutation 2, Yi-Guang Chen
• MGI ID: MGI:6391167
• Synonyms: Ab^g7-S57D, H2-Ab1^em2Ygch
• Gene: H2-Ab1 Location: Chr17:34482201-34488392 bp, + strand Genetic Position: Chr17, 17.98 cM
• Alliance: H2-Ab1^g7-em2Ygch page

Mutation origin

• Strain of Origin: NOD/ShiLtJ

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: The zinc finger nuclease induced mutation targets residue 57 of the gene, resulting in a serine to aspartic acid mutation (S57D). The mutation at position 57 (S57D) in the MHC class II A chain disrupts the expression of the diabetes susceptible MHC class II I-Ag7 molecule uniquely expressed in NOD mice. (J:284226)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any H2-Ab1 Mutation: 82 strains or lines available

References

• Original: J:284226 Chen YG, et al., The Role of NOD Mice in Type 1 Diabetes Research: Lessons from the Past and Recommendations for the Future. Front Endocrinol (Lausanne). 2018;9:51
• All: 2 reference(s)