Tg(TcraY5,TcrbY5)459Tdsc
Transgene Detail

Summary

• Symbol: Tg(TcraY5,TcrbY5)459Tdsc
• Name: transgene insertion 459, Todd Schell
• MGI ID: MGI:6391077
• Synonyms: TCR-V
• Transgene: Tg(TcraY5,TcrbY5)459Tdsc Location: unknown
• Alliance: Tg(TcraY5,TcrbY5)459Tdsc page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(TcraY5,TcrbY5)459Tdsc expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcra (MGI:98553)	expresses Valpha4.1-Jalpha18
  mouse	Tcrb (MGI:98578)	expresses Vbeta7-Jbeta1.3

• Mutation details: The transgene construct contains sequences from the alpha and beta-chains of the T cell receptor (TCR) from the SV40 large tumor antigen epitope IV-specific cytotoxic T lymphocyte clone Y-5. The TCR subunits express Vbeta7-Jbeta1.3and Valpha4.1-Jalpha18. (J:284225)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:284225 Otahal P, et al., Inefficient cross-presentation limits the CD8+ T cell response to a subdominant tumor antigen epitope. J Immunol. 2005 Jul 15;175(2):700-12
• All: 1 reference(s)