Tg(CAG-OVAL*)USA9Jjmn
Transgene Detail

Summary

• Symbol: Tg(CAG-OVAL*)USA9Jjmn
• Name: transgene insertion USA9, James J Moon
• MGI ID: MGI:6390908
• Synonyms: Tg(CAG-OVA/2W/GP33/GP66/H2-D)9Jjmn, Tg(CAG-USA)9Moon
• Transgene: Tg(CAG-OVAL*)USA9Jjmn Location: unknown
• Alliance: Tg(CAG-OVAL*)USA9Jjmn page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-OVAL*)USA9Jjmn expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  chicken	OVAL (396058)

• Tg(CAG-OVAL*)USA9Jjmn expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  chicken	CAG

• Mutation details: This randomly integrated transgene encodes a membrane-bound (using the transmembrane domain of the mouse H2-D^b) version of chicken ovalbumin in which additional T cell antigenic peptide epitopes are embedded. These additional epitopes include 2W1S (EAWGALANWAVDSA), and lymphocytic choriomeningitis virus (LCMV) gp33 (KAVYNFATM) and gp66 (DIYKGVYQFKSV), which function as the Universal Self Antigen (USA). Expression is driven by the CAG (beta actin) promoter, and is made conditional by the upstream insertion of a transcriptional stop signal flanked by loxP sites. (J:284012)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:284012 Zhang Z, et al., Opposing peripheral fates of tissue-restricted self antigen-specific conventional and regulatory CD4+ T cells. Eur J Immunol. 2020;50(1):63-72
• All: 3 reference(s)