Rgs12^tm2.1Dski
Targeted Allele Detail

Summary

• Symbol: Rgs12^tm2.1Dski
• Name: regulator of G-protein signaling 12; targeted mutation 2.1, David Siderovski
• MGI ID: MGI:6389571
• Synonyms: Rgs12^fl, Rgs12^tm2.1Vse
• Gene: Rgs12 Location: Chr5:35106789-35196988 bp, + strand Genetic Position: Chr5, 17.96 cM
• Alliance: Rgs12^tm2.1Dski page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:260028
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site and FRT flanked neo cassette were inserted upstream of exon 5 and a loxP site was inserted downstream of exon 6 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:260028)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rgs12 Mutation: 61 strains or lines available

References

• Original: J:260028 Gross JD, et al., Regulator of G protein signaling-12 modulates the dopamine transporter in ventral striatum and locomotor responses to psychostimulants. J Psychopharmacol. 2018 Feb;32(2):191-203
• All: 2 reference(s)